Case Reports and Reviews: Open Access

Abstract 

Introduction: Type 2 diabetes is a multifactorial disease whose hyperglycemia is linked to a reduction in insulin secretion and insulin sensitivity, combined with lipid metabolism disorders. Management of the disease requires not only exploration of carbohydrate metabolism, but also measurement of certain lipid parameters. Materials and Methods: This study was carried out in 100 patients with type 2 diabetes. In these patients, venous blood samples were taken after a minimum 12 hours fast. Parameters such as insulin, fasting blood glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides (TG) were measured using the ARCHITECT plus Ci4100 automated system. Results: The mean age of patients was 55.1 ± 12.1 years; 43 patients were aged under 55 and 57 patients were aged 55 or over, respectively 43.% and 57%. We noted 61 women and 39 men, or 61% and 39% respectively, with a sex ratio 0.63. The results also showed that 75% of patients had an insulin level ˂ 11mUI/l and 25% a level ≥ 11 mUI/l. Some of the patients had total hypercholesterolemia, hyperLDLaemia, hypoHDLaemia, hypertriglyceridemia with percentages of 90, 67, 95 and 22 respectively. A statistically significant negative correlation between insulin and blood glucose was found (p-value < 0.05). On the other hand, the correlation between insulin and lipid parameters was not statistically significant. Conclusion: Our study shows that insulin resistance plays an important role in the pathophysiology of dyslipidemia in type 2 diabetes.
 

Keywords: Insulin and Type 2 diabetes.