Case Reports and Reviews: Open Access

Abstract 

Odontogenic cysts and tumors are originated from clusters of cell rests of dental lamina retained in the tissues. The capacities with regards to additional expansion of these epithelial leftovers during cysts and tumors formation are at variance. CD10 is an enzyme endopeptidase, used to identify tumor cell differentiation and multiplication as well as prognosis of various types of tumors. Studies on behavior and aggressiveness of odontogenic lesions are still scarce. This article aimed to compare the immunohistochemical expression of CD10 in dentigerous cyst (DC), odontogenic keratocyst (OKC) and unicystic ameloblastoma (UA). In this laboratory based cross-sectional comparative study, immunohistochemical staining of CD10 was performed on histologically proven thirty-nine odontogenic lesions (13 DC, 13 OKC, and 13 UA). Results were statistically analyzed by using Chi-squared test, paired sample t-test, and independent t-test. Data showed mean percentage of CD10 immunoexpression was the highest in epithelial part of UA (63.85 ± 24.34) compared to DC (45.0 ± 23.28) and OKC (43.85 ± 28.44). CD10 immunoexpression was higher in stromal parts of UA and OKC (68.46 ± 17.25 and 64.23 ± 19.88 respectively) than DC (21.54 ± 15.73). There was statistically significant difference between CD10 epithelial immunoexpression and stromal immunoexpression within study groups (p = 0.021). Current data proposed that aggressiveness of UA and high recurrence rate of OKC might be related to increase in immunoexpression of CD10. It is indicated for surgical modification of these lesions compared to DC and recommended for regular follow-up. 

Keywords: Dentigerous cyst; Odontogenic keratocyst; Unicystic ameloblastoma; CD10; Immunohistochemistry.