Case Reports and Reviews: Open Access

Abstract
Introduction: Skeletal striated muscle has the capacity to convert chemical into mechanical energy, enabling contraction that ensures body movement in the form of muscle work. Muscle deficiencies or injuries compromise the function of this tissue in the body and are classified according to their severity. This condition affects the performance of individuals in activities of daily living, as well as their quality of life. Given the potential of tissue engineering to promote muscle recovery, the aim of this narrative review is to describe techniques that promote skeletal muscle regeneration using spinal muscular atrophy as a model. Materials and Methods: Searches were performed in the following databases: United States National Library of Medicine (MEDLINE) via PubMed; Latin American and Caribbean Health Sciences Literature (Lilacs); Cochrane Library; SciVerse Scopus; Web of Science, and Scientific Electronic Library Online (SciELO). Results: Using biopolymers and extracellular matrices, tissue engineering attempts to recreate organic tissues capable of regenerating injured tissues or mimicking their activities. Scaffolds produced from animal extracellular matrix, as well as hydrogels and synthetic materials, have been shown to provide support for the growth of new cells in injured tissues. Conclusion: Methods developed by tissue engineering aimed at the repair of muscle injuries are important to improve the quality of life of patients. Thus, techniques using bioresorbable materials, such as decellularized biological scaffolds and hydrogels, are promising in the regeneration of muscles, contributing to the recovery of their motor capacity.
 

Keywords: Muscle regeneration; Bioresorbable polymers; Skeletal muscle; Tissue regeneration; and Spinal muscular atrophy.